ÖZET

Amaç:

Erdostein’in (ERD) farmasötik formülasyonlarında tayini için iki basit, hızlı ve hassas yöntem geliştirilmiştir.

Yöntemler:

Metotların esası, kloranil (CA) ve 7,7,8,8-tetrasiyanokinodimetan (TCNQ) ile ERD arasında renkli yük transfer komplekslerinin oluşturulmasına dayanmaktadır. Maksimum dalga boyları CA ve TCNQ yöntemleri için sırasıyla 454 ve 843 nm’de ölçülmüştür. Deney koşullarının optimizasyonu araştırılmıştır.

Bulgular:

Beer kuralı, CA ve TCNQ metotları için sırasıyla 10-500 μg mL^-1 ve 20-600 μg mL^-1 konsantrasyon aralığında bulundu. Yöntemler özgünlük, doğrusallık, doğruluk, kesinlik, gözlenebilme sınırı, tayin sınırı gibi validasyon parametreleri açısından değerlendirildi.

Sonuç:

Metodlar ayrıca ilaç içeren kapsüllerde ERD’nin tayininde de başarıyla uygulandı. Geliştirilen yeni spektrofotometrik metotların oldukça pratik ve uygulanabilir olduğu belirlenmiştir. Örnek hazırlama aşamasında karmaşık numune hazırlama işlemlerine gereksinim duyulmaması yöntemin uygulanabilirliğini artırmaktadır.

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Erdostein’in Kapsül Dozaj Formlarında Spektrofotometrik Olarak Analizi

ÖZET

References