ÖZET
Amaç:
Fraktal analiz (FA), karmaşık ve düzensiz vücut yapılarının değerlendirilmesini matematik yoluyla gerçekleştiren bir yöntemdir. Bu çalışmanın amacı, FA yaklaşımını panoramik radyografiler üzerinde sigaranın mandibuler trabeküler kemik yapısını nasıl etkilediğini belirlemede kullanmaktır.
Yöntemler:
Sigara içen 55 kişi olgu grubunu oluştururken, sigara içmeyen 55 kişi kontrol grubu olarak belirlendi. Çalışma ve kontrol grupları yaş ve cinsiyet açısından eşleştirildi. Sağ mandibuler angulus ve sağ ikinci premolar ile birinci molar kökler (interdental) arasındaki trabeküler kemik bölgesinden 100x100 piksel boyutunda iki ilgi alanı (ROI) belirlendi. Panoramik radyografi ile belirlenen ROI’lar üzerinde kutu sayma tekniği kullanılarak FA yapıldı. Verilerin analizinde IBM Corp tarafından Armonk, NY, ABD’de geliştirilen SPSS 21.0 programı kullanıldı. P değeri 0,05 eşiğinde anlamlı olarak kabul edildi.
Bulgular:
Çalışmaya dahil edilen 74 erkek ve 36 kadın bireyin yaş ortalaması 23,54±3,57 idi. Gonial (p=0,528) ve interdental bölgenin (p=0,490) fraktal boyut (FB) değerleri olgu-kontrol grupları arasında istatistiksel olarak birbirinden farklı değildi (p>0,05). Sigara maruziyetine ilişkin paket-yıl değerleri ile FB ölçümlerinin korelasyon analizi yapıldığında istatistiksel olarak anlamlı olmayan negatif ilişki saptandı (p>0,05).
Sonuç:
Sigara maruziyeti arttıkça, FB değerleri azalma eğilimi gösterir. Sigara içmenin mandibuler trabeküler kemik FB değerlerine etkisi gözlenmemiştir.
References
1
Chen J, Zheng B, Chang YH, Shaw CC, Towers JD, Gur D. Fractal analysis of trabecular patterns in projection radiographs. An assessment. Invest Radiol 1994;29:624-9.
2
Sánchez I, Uzcátegui G. Fractals in dentistry. J Dent 2011;39:273-92.
3
Jolley L, Majumdar S, Kapila S. Technical factors in fractal analysis of periapical radiographs. Dentomaxillofac Radiol 2006;35:393-7.
4
Bollen AM, Taguchi A, Hujoel PP, Hollender LG. Fractal dimension on dental radiographs. Dentomaxillofac Radiol 2001;30:270-5.
5
Demirbaş AK, Ergün S, Güneri P, Aktener BO, Boyacioğlu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:e41-8.
6
Ergün S, Saraçoglu A, Güneri P, Ozpinar B. Application of fractal analysis in hyperparathyroidism. Dentomaxillofac Radiol 2009;38:281-8.
7
Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder. Chem Res Toxicol 2001;14:767-90.
8
Caliri AW, Tommasi S, Besaratinia A. Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation Research/Reviews in Mutation Research 2021;787:108365.
9
Dönder A, Balahoroğlu R, Dülger H, Sekeroğlu MR. Sigara ve böbrek fonksiyonları. Eur J Basic Med Sci 2014;4:16-21.
10
Kondo T, Nakano Y, Adachi S, Murohara T. Effects of tobacco smoking on cardiovascular disease. Circ J 2019;83:1980-5.
11
Smilin Bell Aseerwatham G, Choi S, Krishnan JKR. Cigarette smoke and related risk factors in neurological disorders: An update. Biomedicine & Pharmacotherapy 2017;85:79-86.
12
Moreno-Gonzalez I, Estrada LD, Sanchez-Mejias E, Soto C. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Nat Commun 2013;4:1495.
13
Lorentzon M, Mellström D, Haug E, Ohlsson C. Smoking Is Associated with Lower Bone Mineral Density and Reduced Cortical Thickness in Young Men. J Clin Endocrinol Metab 2007;92:497-503.
14
Al-Bashaireh AM, Haddad LG, Weaver M, Chengguo X, Kelly DL, Yoon S. The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms. J Osteoporos 2018;2018:1206235.
15
Güleç M, Taşsöker M, Şener S. Fractal Analysis in Medicine and Dentistry. EÜ Dişhek Fak Derg 2019;40:17-31.
16
Updike SX, Nowzari H. Fractal analysis of dental radiographs to detect periodontitis-induced trabecular changes. J Periodontal Res 2008;43:658-64.
17
Chen SK, Oviir T, Lin CH, Leu LJ, Cho BH, Hollender L. Digital imaging analysis with mathematical morphology and fractal dimension for evaluation of periapical lesions following endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:467-72.
18
Wilding RJ, Slabbert JC, Kathree H, Owen CP, Crombie K, Delport P. The use of fractal analysis to reveal remodelling in human alveolar bone following the placement of dental implants. Arch Oral Biol 1995;40:61-72.
19
Arsan B, Köse TE, Çene E, Özcan İ. Assessment of the trabecular structure of mandibular condyles in patients with temporomandibular disorders using fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 2017;123:382-91.
20
Nance R, Delaney J, McEvoy JW, Blaha MJ, Burke GL, Navas-Acien A, et al. Smoking intensity (pack/day) is a better measure than pack-years or smoking status for modeling cardiovascular disease outcomes. J Clin Epidemiol 2017;81:111-9.
21
White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:628-35.
22
Zeytinoğlu M, İlhan B, Dündar N, Boyacioğlu H. Fractal analysis for the assessment of trabecular peri-implant alveolar bone using panoramic radiographs. Clin Oral Investig 2015;19:519-24.
23
Amer ME, Heo MS, Brooks SL, Benavides E. Anatomical variations of trabecular bone structure in intraoral radiographs using fractal and particles count analyses. Imaging Sci Dent 2012;42:5-12.
24
Shrout MK, Farley BA, Patt SM, Potter BJ, Hildebolt CF, Pilgram TK, et al. The effect of region of interest variations on morphologic operations data and gray-level values extracted from digitized dental radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:636-9.
25
Gumussoy I, Miloglu O, Cankaya E, Bayrakdar IS. Fractal properties of the trabecular pattern of the mandible in chronic renal failure. Dentomaxillofac Radiol 2016;45:20150389.
26
Neves FS, Barros AS, Cerqueira GA, Cruz GA, Reis AA, Alves LB, et al. Assessment of fractal dimension and panoramic radiomorphometric indices in women with celiac disease. Oral Radiol 2020;36:141-7.
27
Canturk F, Miloglu O, Gumussoy I, Dayanan R. The Investigation of Radiographic Findings of Mandibles on of with primary hyperparathyroidism using fractal analysis. The Eurasian J Med 2021;53:185-92.
28
Kolcakoglu K, Amuk M, Sirin Sarıbal G. Evaluation of mandibular trabecular bone by fractal analysis on panoramic radiograph in paediatric patients with sleep bruxism. Int J Paediatr Dent 2022;32:776-84.
29
Korkmaz YN, Arslan S. Evaluation of the trabecular structure of the mandibular condyles by fractal analysis in patients with different dentofacial skeletal patterns. Australasian Orthodontic Journal 2021;37:93-9.
30
Güleç M, Taşsöker M, Özcan S. Fractal dimension of mandibular trabecular bone: What is the importance of age, gender and region of interest selection? Selcuk Dent J 2019;6:15-9.
31
Ruttimann UE, Webber RL, Hazelrig JB. Fractal dimension from radiographs of peridental alveolar bone. A possible diagnostic indicator of osteoporosis. Oral Surg Oral Med Oral Pathol 1992;74:98-110.
32
Oliveira ML, Pedrosa EF, Cruz AD, Haiter-Neto F, Paula FJ, Watanabe PC. Relationship between bone mineral density and trabecular bone pattern in postmenopausal osteoporotic Brazilian women. Clin Oral Investig 2013;17:1847-53.
33
Sanchez-Molina D, Velazquez-Ameijide J, Quintana V, Arregui-Dalmases C, Crandall JR, Subit D, et al. Fractal dimension and mechanical properties of human cortical bone. Med Eng Phys 2013;35:576-82.
34
Yasar F, Akgünlü F. Fractal dimension and lacunarity analysis of dental radiographs. Dentomaxillofac Radiol 2005;34:261-7.
35
Sørensen LT, Toft BG, Rygaard J, Ladelund S, Paddon M, James T, et al. Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism. Surgery 2010;148:982-90.
36
Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (London, England : 1979). 2007;113:233-41.
37
Hadley MN, Reddy SVJN. Smoking and the human vertebral column: a review of the impact of cigarette use on vertebral bone metabolism and spinal fusion. Neurosurgery 1997;41:116-24.
38
Law MR, Cheng R, Hackshaw AK, Allaway S, Hale AK. Cigarette smoking, sex hormones and bone density in women. Eur J Epidemiol 1997;13:553-8.
39
Nogueira L, Breen EC. Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone. Am J Respir Cell Mol Biol 2021;64:533-5.
40
Weng W, Li H, Zhu S. An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis. Genes 2022;13:806.
41
Vogel JM, Davis JW, Nomura A, Wasnich RD, Ross PD. The effects of smoking on bone mass and the rates of bone loss among elderly Japanese-American men. J Bone Min Res 1997;12:1495-501.
42
Pereira ML, Carvalho JC, Peres F, Fernandes MH. Effect of nicotine in matrix mineralization by human bone marrow and Saos-2 cells cultured on the surface of plasma-sprayed titanium implants. Journal of biomedical materials research Part A. 2009;88(1):84-93.
43
DeLuca S, Habsha E, Zarb GA. The effect of smoking on osseointegrated dental implants. Part I: implant survival. Int J Prosthod 2006;19:491-8.
44
Camargo RCT, Costalonga RR, Louzada MJQ, Fernandes RA, Camargo JCSF, Urban JB. The Influence of Passive Tobacco Exposure and Physical Exercise on Bone Tissue of Young Rats. Acta Ortop Bras 2017;25:77-80.
45
Rosa RC, Pereira SC, Cardoso FAG, Caetano AG, Santiago HARd, Volpon JB. Second hand tobacco smoke adversely affects the bone of immature rats. Clinics 2017;72:785-9.
46
Keaveny TM, Yeh OC. Architecture and trabecular bone - toward an improved understanding of the biomechanical effects of age, sex and osteoporosis. J Musculoskelet Neuronal Interact 2002;2:205-8.
