ÖZET

Amaç:

Epikardiyal yağ dokusu, kalbin kasılma aktivitesi için lokal enerji kaynağıdır. Bununla birlikte, chemerin, yağ dokusundan salınan yeni bir kemoatraktan adipositokindir. Chemerin ve reseptörü epikardiyal yağ dokusunda ve kardiyomiyositlerde tespit edilmiştir. Hipertansiyon, diyabet, obezite, dislipidemi, koroner kalp hastalığı ve atriyal fibrilasyon gibi kardiyovasküler hastalıklar ile chemerin arasındaki ilişki önceki çalışmalarda gösterilmiştir. Birçok aritmi tipinden biri olan supraventriküler taşikardinin (SVT) nedenleri hala net olarak bilinmediğinden, SVT hala hayatı tehdit eden önemli bir morbidite kaynağıdır. Bu çalışmada kardiyovasküler hastalıklarla ilişkisi olan plazma chemerin düzeylerinin SVT ile olası ilişkilerinin belirlenmesi amaçlanmıştır.

Yöntemler:

Bu çalışmaya kardiyoloji kliniği tarafından SVT tanısı konulan toplam 62 hasta ve 27 kontrol dahil edildi. Hematolojik ve serum biyokimya parametreleri analiz edildi. Plazma chemerin konsantrasyonları ELISA tekniği ile ölçüldü.

Bulgular:

Chemerin düzeyleri kontrol grubuna göre SVT grubunda istatistiksel olarak anlamlı düzeylerde daha yüksekti (p<0,001). Dakikadaki kalp hızı, kontrol grubunda hasta grubuna göre anlamlı derecede düşüktü (p<0,001). Pearson korelasyon analizi, plazmadaki chemerin seviyeleri ile ortalama kalp hızı arasında pozitif korelasyon olduğunu ortaya koydu. Ayrıca nötrofil/lenfosit oranı SVT grubunda kontrol grubuna göre anlamlı derecede yüksekti (1,95±26,53 vs. 1,42±0,7, p<0,01).

Sonuç: Bu çalışma ilk kez SVT’de plazma chemerin düzeylerinin yüksek olduğunu gösterdi. Ayrıca bu çalışma yüksek plazma chemerin konsantrasyonları ile kalp atım hızı arasında pozitif bir korelasyon olduğunu belirledi. Kardiyovasküler hastalıklar, enflamasyon, metabolik sendrom ve daha birçok hastalıkla ilişkisi bulunan chemerinin dolaşımdaki seviyelerini belirlemek ve düzeylerini kontrol etmek SVT’de önemli olabilir.

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Plazma Chemerin Seviyeleri ile Supraventriküler Taşikardi Arasındaki İlişki

ÖZET

References