ÖZET
Amaç:
Bu çalışmanın amacı, sıçanlarda femoral arter insizyon modelinde üç farklı fiziksel formda (sıvı, toz ve spança emdirilmiş) bulunan Algan Hemostatik Ajanın (AHA) etkinliğini değerlendirmektir.
Yöntemler:
Çalışmada toplam 64 adet 5-7 haftalık rat kullanıldı. Ratlar rastgele olarak her biri sekiz rattan oluşan 4 gruba (4 grup heparinize ve 4 grup nonheparinize) ayrıldı. Deneysel femoral arter insizyonu oluşturuldu. Kontrol olarak serum fizyolojik emdirilmiş spanç uygulandı. Deney gruplarına AHA sıvısı, AHA tozu ve AHA sıvısı emdirilmiş spanç formları uygulandı.
Bulgular:
Kanama bölgelerine uygulanan tüm AHA formları kontrol grubuna göre anlamlı olarak daha kısa sürede kanamayı durdurdu (p<0.05). Buna karşılık, kontrol grubunda kanama 4 dakika içinde kontrol edilemedi. En iyi sonuç AHA toz formundaydı ve heparinize olmayan grupta kanamayı birinci dakikada %87,5 ve ikinci dakikada %12,5 oranında kontrol edebildi. Heparinize grupta AHA toz formu birinci dakikada %62,5, ikinci dakikada ise %37,5 oranında kanamayı kontrol edebildi.
Sonuç:
Bu çalışma, AHA'nın kanama kontrolünde oldukça etkili ve umut verici bir hemostatik ajan olduğunu göstermektedir.
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