Golgi Aparatı: Morfoloji ve İşlev Son Gelişmeler ile Birlikte
PDF
Atıf
Paylaş
Talep
P: 331-338
Ekim 2019

Golgi Aparatı: Morfoloji ve İşlev Son Gelişmeler ile Birlikte

Bezmialem Science 2019;7(4):331-338
Bilgi mevcut değil.
Bilgi mevcut değil
Alındığı Tarih: 24.09.2018
Kabul Tarihi: 12.02.2019
Yayın Tarihi: 28.10.2019
PDF
Atıf
Paylaş
Talep

ÖZET

Sekretuvar yolun merkezinde olan Golgi kompleksi, ürünlerin doğru işlenmesini, işaretlenmesini ve sitoplazma, plazma membranı veya endozom-lizozom sistemi gibi son hedeflerine ulaştırılmasını garanti altına alır. Son teknolojik gelişmeler Golgi apparatusunun yeni morfolojik ve fonksiyonel özelliklerinin keşfedilmesini sağlamıştır. Bu derlemede, Golgi apparatusunun stabil bir organel olmadığını, aksine çeşitli fizyolojik ve patolojik durumlarda morfolojik ve fonksiyonel özelliklerini değiştiren oldukça dinamik bir organel olduğunu vurgulamaktayım. Golgi apparatusu basitçe birbirine parallel keselerden ibaret olmayıp, kaplı veziküller, vakuoller ve tübüller içeren cis-Golgi ağı, trans-Golgi ağı ve intersisternal ağ gibi bölümlerden oluşur. Dahası sadece sekretuvar yolda görev almaz, ayrıca agranüler endoplazma retikulumu gibi Ca2+ depolanmasında rol oynar. Bunlara ilaveten özellikle bölünmeden sonra kendisinin yeniden yapılanmasına katkıda bulunan mikrotübülleri oluşturan bir mikrotübül organize edici merkez olarak da görev alabilir.

References

1
Esrefoglu M. The cell: A microscopic and functional approach. 1st ed. Berlin: Lambert Academic Publishing; 2018. 
2
Boncompain G, Weigel AV. Transport and sorting in the Golgi complex: multiple mechanisms sort diverse cargo.  Curr Opinion Cell Biol 2018;50:94-101.
3
Mellman I, Warren G. The road taken: past and future foundations of membrane traffic. Cell 2000;100:99-112.
4
Misteli T, Warren G. Mitotic disassembly of the Golgi apparatus in vivo. J Cell Sci 1995;108:2715-27.
5
Marra P, Salvatore L, Mironov A, Jr. Di Campli A, Di Tullio G, Trucco A, et al. The biogenesis of the Golgi ribbon: The roles of membrane input from the ER and of GM130. Mol Biol Cell 2007;18:1595-608.
6
Sütterlin C, Colanzi A. The Golgi and the centrosome: Building a functional partnership. J Cell Biol 2010;188:621-8.
7
Munro S. The golgin coiled-coil proteins of the Golgi apparatus. Cold Spring Harb Perspect Biol 2011;3:a005256.
8
Lowe M. Structural organization of the Golgi apparatus. Curr Opin Cell Biol 2011;23:85-93.
9
Rios RM, Bornens M. The Golgi apparatus at the cell centre. Curr Opin Cell Biol 2003;15:60-6.
10
Colanzi A, Süterlin C. Signaling at the Golgi During Mitosis.  Methods  Cell Biol 2013;118:383-400.
11
Papanikou E, Glick BS. The yeast Golgi apparatus: Insights and mysteries. FEBS Lett  2009;583:3746-51.
12
Xiang Y, Zhang X, Nix DB, Katoh T, Aoki K, Tiemeyer M, et al. Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. Nat Comm 2013;4:1659.
13
Puthenveedu MA, Bachert C, Puri S, Lanni F, Linstedt AD. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. Nat Cell Biol 2006;8:238-48.
14
Kondylis V, Rabouille C. The Golgi apparatus: Lessons from Drosophila. FEBS Lett 2009;583:827-38.
15
Shorter J, Warren G. Golgi architecture and inheritance. Annu Rev Cell Dev Biol 2002;18:379-420.
16
De Matteis MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway. J Cell Sci 2000;113:2331-43.
17
Ward TH, Polishchuk RS, Caplan S, Hirschberg K, Lippincott-Schwartz J. Maintenance of Golgi structure and function depends on the integrity of ER export. J Cell Biol 2001;155:557-70.
18
Colanzi A, Hidalgo Carcedo C, Persico A, Cericola C, Turacchio G, Bonazzi M, et al. The Golgi mitotic checkpoint is controlled by BARS-dependent fission of the Golgi ribbon into separate stacks in G2. EMBO J 2007;26:2465-76.
19
Colanzi A, Suetterlin C, Malhotra V. Cell-cycle-specific Golgi fragmentation: How and why? Curr Opin Cell Biol 2003;15:462-7.
20
Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, et al. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci USA 2006;103:17777-82.
21
Zhang X, Wang Y. GRASPs in Golgi structure and function. Front Cell Dev Biol 2016;3:1-8.
22
Mollenhauer HH, Morré DJ. Perspectives on Golgi apparatus form and function. J Electron Microsc Tech 1991;17:2-14.
23
Bonfanti L, Mironov AA Jr, Martínez-Menárguez JA, Martella O, Fusella A, Baldassarre M, et al. Procollagen traverses the Golgi stack without leaving the lumen of cisternae: evidence for cisternal maturation. Cell 1998;95:993-1003.
24
Presley JF, Cole NB, Schroer TA, Hirschberg K, Zaal KJ, Lippincott-Schwartz J. ER-to-Golgi transport visualized in living cells. Nature 1997;389:81-5.
25
Marsh BJ, Mastronarde DN, McIntosh JR, Howell KE. Structural evidence for multiple transport mechanisms through the Golgi in the pancreatic beta-cell line, HIT-T15. Biochem Soc Trans 2001;29:461-7.
26
Hauri HP, Schweizer A. The endoplasmic reticulum-Golgi intermediate compartment. Curr Opin Cell Biol 1992;4:600-8.
27
Mogelsvang S, Marsh BJ, Ladinsky MS, Howell KE. Predicting function from structure: 3D structure studies of the mammalian Golgi complex. Traffic 2004;5:338-45.
28
Zappa F, Failli M, De Matteis A. The Golgi complex in disease and therapy. Curr Opin Cell Biol 2018;50:102-16.
29
Hughes H, Stephens DJ. Assembly, organization, and function of the COPII coat. Histochem Cell Biol 2008;129:129-51.
30
Mironov AA, Mironov Jr AA, Beznoussenko GV, Trucco A, Lupetti P, Smith JD, et al. ER-to-Golgi carriers arise through direct en blocprotrusion and multistage maturation of specialized ER exit domains. Dev Cell 2003;5:583-94.
31
Bannykh SI, Rowe T, Balch WE. The organization of endoplasmicreticulum export complexes. J Cell Biol 1996;135:19-35.
32
Bannykh SI, Nishimura N, Balch WE. Getting into the Golgi. Trends Cell Biol 1998;8:21-5.
33
Saraste J, Kuismanen E. Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface. Cell 1984;38:535-49.
34
Herzog CA, Hauri FP. The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function.  J Cell Sci 2006;119:2173-83.
35
Saraste J Dale HA, Bazzocco S, Marie M. Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking. FEBS Lett 2009;583:3804-10.
36
Marie M, Dale HA, Sannerud R, Saraste J. The function of the intermediate compartment in pre-Golgi trafficking involves its stable connection with the centrosome. Mol Biol Cell 2009;20:4458-70.
37
Sannerud R, Marie M, Nizak C, Dale HA, Pernet-Gallay K, Perez F, et al. Rab1 defines a novel pathway connecting the pre- Golgi intermediate compartment with the cell periphery. Mol Biol Cell 2006;17:1514-26.
38
Palmer KJ, Watson P, Stephens DJ. The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Biochem Soc Symp 2005;72:1-13.
39
Gillingham AK, Munro S. Finding the Golgi: golgin coiled-coil proteins show the way. Trends Cell Biol 2016;26:399-408.
40
Witkos TM, Lowe M. Recognition and tethering of transport vesicles at the Golgi apparatus. Curr Opin Cell Biol 2017;47:16-23.
41
Trucco A, Polishchuk RS, Martella O, Di Pentima A, Fusella A, DiGiandomenico D, et al. Secretory traffic triggers the formation of tubularcontinuities across Golgi sub-compartments. Nat Cell Biol 2004;6:1071-81.
42
Koreishi M, Gniadek TJ, Yu S, Masuda J, Honjo Y, Satoh A. The golgin tether giantin regulates the secretory pathway by controlling stack organization within Golgi apparatus. PLoS One 2013;8:e59821.
43
Willett R, Ungar D, Lupashin V. The Golgi puppet master: COG complex at center stage of membrane trafficking interactions. Histochem Cell Biol 2013;140:271-83.
44
Béthune J, Wieland F, Moelleken J. COPI-mediated transport. J Membr Biol 2006;211:65-79.
45
Glick BS, Elston T, Oster G. A cisternal maturation mechanism can explain the asymmetry of the Golgi stack. FEBS Lett 1997;414:177-81.
46
Sabesin SM, Frase S. Electron microscopic studies of the assembly,intracellular transport, and secretion of chylomicrons by rat intestine. J Lipid Res 1977;18:496-511.
47
Mironov AA, Sesorova IS, Seliverstova EV, Beznoussenko GV. Different Golgi ultrastructure across species and tissues: Implications under functional and pathological conditions, and an attempt at classification. Tissue Cell 2017;49:186-201.
48
Tanaka K, Mitsushima A, Fukudome H, Kashima Y. Three-dimensional architecture of the Golgi complex observed by high resolution scanning electron microscopy. J Submicrosc Cytol 1986;18:1-9.
49
Rambourg A, Clermont Y. Three-dimensional structure of the Golgi apparatus in mammalian cells. In: Roth J, Berger EG, editors. The Golgi Apparatus. Basel: Birkhauser; 1997.pp.37-611. 
50
Nakano A, Luini A. Passage through the Golgi. Curr Opin Cell Biol 2010;22:471–78.
51
Braulke T, Bonifacino JS. Sorting of lysosomal proteins. Biochim Biophys Acta 2009;1793:605-14.
52
Alberts B, Johnson A,  Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. 4th ed. New York: Garland Science. 2002.
53
Kornfeld S, Mellman I. The biogenesis of lysosomes. Annu Rev Cell Biol 1989;5:483-525.
54
Coutinho MF, Prata MJ, Alves S. A shortcut to the lysosome: The mannose-6-phosphate-independent pathway. Mol Genet Metab 2012;107:257-66.
55
Ni X, Canuel M, Morales CR. The sorting and trafficking of lysosomal proteins. Histol Histopathol 2006;21:899-913.
56
Lefrancois S, Zeng J, Hassan AJ, Canuel M, Morales CR. The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin. EMBO J 2003;22:6430-7.
57
Canuel M, Korkidakis A, Konnyu K, Morales CR. Sortilin mediates the lysosomal targeting of cathepsins D and H. Biochem Biophys Res Commun 2008;373:292-7.
58
Novikoff PM, Novikoff AB, Quintana N, Hauw JJ. Golgi apparatus, GERL, and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry. J Cell Biol 1971;50:859-86.
59
Rabouille C, Hui N, Hunte F, Kieckbusch R, Berger EG, Warren G, et al. Mapping the distribution of Golgi enzymes involved in the constructionof complex oligosaccharides. J Cell Sci 1995;108:1617-27.
60
Pizzo P, Lissandron V, Capitanio P, Pozzan T. Ca2+ signalling in the Golgi apparatus. Cell Calcium  2011;50:184-92.
61
Chandra S, Kable EP, Morrison GH,  Webb WW. Calcium sequestration in the Golgi apparatus of cultured mammalian cells revealed by laser scanning confocal microscopy and ion microscopy. J Cell Sci 1991;100:747-52.
62
Missiaen L, Van Acker K, Van Baelen K, Raeymaekers L, Wuytack F, Parys JB, et al. Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments. Cell Calcium 2004;36:479-87.
63
Carnell L, Moore HP. Transport via the regulated secretory pathway in semiintact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II.  J Cell Biol 1994;127:693-705.
64
Ivessa NE, De Lemos-Chiarandini C, Gravotta D, Sabatini DD, Kreibich G. The Brefeldin A-induced retrograde transport from the Golgi apparatus to the endoplasmic reticulum depends on calcium sequestered to intracellular stores. J Biol Chem 1995;270:25960-7.
65
Pizzo P, Lissandron V, Pozzan T. The trans-golgi compartment: A new distinct intracellular Ca store. Commun Integr Biol 2010;3:462-4.
66
Sanders AA, Kaverina I. Nucleation and dynamics of Golgi derived microtubules. Front Neurosci 2015;9:431.
67
Zhu X, Kaverina I. Golgi as an MTOC: making microtubules for its own good. Histochem Cell Biol 2013;140:361-7.
68
Hurtado L, Caballero C, Gavilan MP, Cardenas J, Bornen, M, Rios RM. Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis. J Cell Biol 2011;193:917-33.
69
Ori-McKenney KM, Jan LY,  Jan YN. Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron 2012;76:921-30.
2024 ©️ Galenos Publishing House