ÖZET
Amaç:
Bu çalışmada, rasekadotril’in farmasötik preparatlarda tayini için basit ve seçici yeni bir yüksek performanslı sıvı kromatografisi yöntemi geliştirilmiştir.
Yöntemler:
Yöntem ters fazlı C18 kolonda; asetonitril-su (70: 30, h/h) hareketli fazı ile 0,7 mL/minimum akış hızında rasekadotril’in kromatografik olarak analiz edilmesi esasına dayanır.
Bulgular:
Rasekadotril için en uygun dalga boyu 220 nm olarak belirlenmiştir. Rasekadotril için doğrusallık aralığı 5-100 μg/mL olarak bulunmuştur.
Sonuç:
Elde edilen sonuçlar istatistiksel olarak değerlendirildi. Geliştirilen yöntem kolay, kesin ve tekrarlanabilir olup rasekadotril’in farmasötik preparatlarının analizlerinde güvenle kullanılabilir.
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