Öz
Amaç
Bu çalışmanın amacı ileri glikasyon son ürünleri (AGE) ve kanser ilişkisi üzerine yapılan çalışmaların mevcut durumunu analiz etmek ve alandaki ana eğilimleri, öne çıkan yazarları, makaleleri, kurumları, ülkeleri ve iş birliklerini ve konuyla ilgili en popüler anahtar kelimeleri ve anahtar kelimelerin zaman içinde popülerliğindeki değişimi ortaya koymaktır. Bu bağlamda, çalışma ilgili alana odaklanmak isteyen araştırmacılara rehberlik etmeyi ve alandaki bilgilere erişimi kolaylaştırarak gelecekteki araştırmalar için bir temel sağlamayı amaçlamaktadır.
Yöntemler
Ham veriler 30 Nisan 2024’te Web of Science (WoS) Core Collection veritabanından alınmış, Bibliometrix ve VOSviewer gibi programlarla analiz edilmiştir. Yıllık hesaplamalar açısından doğru olması için 2024 yılı verileri dahil edilmemiştir.
Bulgular
WoS’da konuyla ilgili ilk çalışma 1994 yılında yayınlanmıştır. Ülkeler arasında Amerika Birleşik Devletleri (ABD), Çin ve Japonya, yazarlar arasında Takeuchi M., Yamagishi S. ve Kuniyasu H. ve kurumlar arasında Kurume Üniversitesi öne çıkmaktadır. Konuyla ilgili en fazla iş birliği; ülkeler olarak ABD ve Çin arasında, yazarlar olarak Yamagishi S. ve Matsui T. arasındadır.
Sonuç
Bu bibliyometrik analizden elde edilen sonuçlar, AGE’lerin kanser çalışmalarındaki artan önemini vurgulayarak, daha fazla araştırma ve iş birliği çabası için potansiyel yollara işaret etmektedir.
Anahtar Kelimeler: Bibliyometrik analiz, kanser, onkoloji, ileri glikasyon son ürünleri, öfke, beslenme
Kaynakça
Ruiz HH, Ramasamy R, Schmidt AM. Advanced glycation end products: building on the concept of the "common soil" in metabolic disease. Endocrinology. 2020;161:bqz006.
Dyer DG, Dunn JA, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, et al. Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest. 1993;91:2463-9.
Semba RD, Nicklett EJ, Ferrucci L. Does accumulation of advanced glycation end products contribute to the aging phenotype? J Gerontol A Biol Sci Med Sci. 2010;65:963-75.
Hohmann C, Liehr K, Henning C, Fiedler R, Girndt M, Gebert M, et al. Detection of free advanced glycation end products in vivo during hemodialysis. J Agric Food Chem. 2017;65:930-7.
Schröter D, Höhn A. Role of Advanced glycation end products in carcinogenesis and their therapeutic implications. Curr Pharm Des 2019;24:5245-51.
Aragno M, Mastrocola R. Dietary sugars and endogenous formation of advanced glycation endproducts: emerging mechanisms of disease. Nutrients. 2017;9:385.
Lin JA, Wu CH, Lu CC, Hsia SM, Yen GC. Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: an emerging biological factor in cancer onset and progression. Mol Nutr Food Res. 2016;60:1850-64.
Rojas A, Figueroa H, Morales E. Fueling inflammation at tumor microenvironment: the role of multiligand/RAGE axis. Carcinogenesis. 2010;31:334-41.
WHO. Cancer. World Health Organization. Published 2022. Accessed May 11, 2024. https://www.who.int/news-room/fact-sheets/detail/cancer
Woods P. Worldwide Cancer Data. Published 2022. Accessed May 11, 2024. https://www.wcrf.org/cancer-trends/worldwide-cancer-data/
Aria M, Cuccurullo C. Bibliometrix : An R-tool for comprehensive science mapping analysis. J Informetrics. 2017;11:959-75.
van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics. 2017;111:1053-70.
Yıldız Gülhan P, Kurutkan MN. Bibliometric Analysis of covid-19 publications in the field of chest and infectious diseases. Duzce Med J. 2021;23:30-40.
Xia H, Wang L, Wang H. Current research trends, hotspots, and frontiers of medical nutrition therapy on cancer: a bibliometric analysis. Front Oncol. 2023;13.
Youn BY, Lee SY, Cho W, Bae KR, Ko SG, Cheon C. Global trends of nutrition in cancer research: a bibliometric and visualized analysis study over the past 10 years. Int J Environ Res Public Health. 2022;19:4165.
Zhang C, Zhang G, Wu T, Fida S, Zhou M, Song C. The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study. Precis Nutr. 2023;2:p e00054.
Liman PB, Anastasya KS, Salma NM, Yenny Y, Faradilla MA. Research trends in advanced glycation end products and obesity: bibliometric analysis. Nutrients. 2022;14:5255.
World Health Organization (WHO). Global Cancer burden growing, amidst mounting need for services. Published February 1, 2024. Accessed June 13, 2024. https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services.
United Nations General Assembly (UNGA). Prevention and control of non-communicable diseases. Published 2018. Accessed June 13, 2024. https://www.un.org/pga/72/event-latest/prevention-of-non-communicable-diseases/
United Nations (UN). The UN high-level meeting on universal health coverage. Published 2019. Accessed June 13, 2024. https://www.uhc2030.org/un-hlm-2019/
Monteiro CA, Moubarac JC, Levy RB, Canella DS, Louzada MLDC, Cannon G. Household availability of ultra-processed foods and obesity in nineteen European countries. Public Health Nutr. 2018;21:18-26.
Pan American Health Organization. Ultra‑processed Food and Drink Products in Latin America: Sales Trends, Regulatory Policies, and Health Outcomes. Washington, DC: Pan American Health Organization; 2018. Accessed June 13, 2024. https://www.paho.org/handle/10665.2/51094
Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature. 2000;405:354-60.
Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem. 2000;275:40096-105.
de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022;71:1020-32.
Kurume University. About Kurume University. 2024; Available from: https://www.kurume-u.ac.jp/english/.
He L, Wang X, Li C, Wan Y, Fang H. Bibliometric analysis of the 100 top-cited articles on immunotherapy of urological cancer. Hum Vaccin Immunother. 2022;18:2035552.
The University of Texas System. History of the University of Texas System. Published n.d. Accessed July 18, 2025. https://www.utsystem.edu/about/history-university-texas-system.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209-49.
Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127:3029-30.
Xia W, Xu Y, Mao Q, Dong G, Shi R, Wang J, et al. Association of RAGE polymorphisms and cancer risk: a meta-analysis of 27 studies. Med Oncol. 2015;32:442.
Zhao DC, Lu HW, Huang ZH. Association between the receptor for advanced glycation end products gene polymorphisms and cancer risk: a systematic review and meta-analysis. J BUON. 2015;20:614-24.
Liu S TX, He M, Fu X, Zhang Y, Fan H. The receptor for advanced glycation end products gene polymorphisms contribute to cancer susceptibility: evidence from meta-analysis. Int J Clin Exp Med. 2016;9:5867-79.
Bellier J, Nokin MJ, Lardé E, Karoyan P, Peulen O, Castronovo V, et al. Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer. Diabetes Res Clin Pract. 2019;148:200-11.
van Beijnum JR, Buurman WA, Griffioen AW. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis. 2008;11:91-9.
Zhu L, Li X, Chen Y, Fang J, Ge Z. High-mobility group box 1: a novel inducer of the epithelial-mesenchymal transition in colorectal carcinoma. Cancer Lett. 2015;357:527-34.
Wada K, Nakashima Y, Yamakawa M, Hori A, Seishima M, Tanabashi S, et al. Dietary advanced glycation end products and cancer risk in Japan: from the Takayama study. Cancer Sci. 2022;113:2839-48.
Wang J, Liu H, Xie G, Cai W, Xu J. Identification of hub genes and key pathways of dietary advanced glycation end products induced non alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020;21:685-94.
Omofuma OO, Turner DP, Peterson LL, Merchant AT, Zhang J, Steck SE. Dietary advanced glycation end-products (AGE) and risk of breast cancer in the prostate, lung, colorectal and ovarian cancer screening trial (PLCO). Cancer Prev Res (Phila). 2020;13:601-10.
Park SJ, Kim MH, Yang WM. Network pharmacology-based study on the efficacy and mechanism of lonicera japonica thunberg. Applied Sciences. 2022;12:9122.
41. Yuan X, Lv L, Wang R. Mechanism of baoyuan decoction in the treatment of chronic heart failure based on network pharmacology. Indian J Pharm Sci. 2022;83:6.
42. Yu F, Huang X, Liang J, Guan S. Combining gut microbiota data with network pharmacology to explore the mechanism of Danggui Sini decoction action against blood stasis syndrome in rats. Curr Top Nutraceutical Res. 2023;21:291-305.
Wu X, Shi X, Chen X, Yin Z. Advanced glycation end products regulate the receptor of AGEs epigenetically. Front Cell Dev Biol. 2023;11:1062229.
Andrade FO, Jin L, Clarke R, Wood I, Dutton M, Anjorin C, et al. Social isolation activates dormant mammary tumors, and modifies inflammatory and mitochondrial metabolic pathways in the rat mammary gland. Cells. 2023;12:961.
Magna M, Hwang GH, McIntosh A, Drews-Elger K, Takabatake M, Ikeda A, et al. RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer. NPJ Breast Cancer. 2023;9:59.
