Tip 2 Diabetes Mellitus’un Alzheimer Hastalığının Gelişimindeki Etkisi ve Moleküler Mekanizmaları

Rabia DURAN; Sümeyra PANCUR; Fatemeh BAHADORİ

doi:10.14235/bas.galenos.2020.4491

Tip 2 Diabetes Mellitus’un Alzheimer Hastalığının Gelişimindeki Etkisi ve Moleküler Mekanizmaları

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Tip 2 Diabetes Mellitus’un Alzheimer Hastalığının Gelişimindeki Etkisi ve Moleküler Mekanizmaları

Bezmialem Science 2022;10(1):114-122 DOI: 10.14235/bas.galenos.2020.4491

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İzin

Öz

Diyabet ve Alzheimer hastalığı (AH) arasındaki ilişkiyi işaret eden epidemiyolojik çalışmaların artmasının ardından, Tip 2 diyabetin AH patolojisinin oluşumunda bir risk faktörü olduğu bildirilmiştir. Beyinde gelişen insülin rezistansı, insülin sinyal iletim sisteminde ve glukoz metabolizmasında bozuklukların meydana gelmesi en olası patofizyolojik sebepler arasında gösterilmiştir. Tip 2 diyabet modeli sıçanlarda fosfo tau ve Aβ gibi AH belirteçlerinin arttığı bununla beraber insülin reseptör (IR) sinyalinin ve insülin benzeri büyüme faktörü-1 reseptörlerinin (IGF-1R) azaldığı bildirilmiştir. Ayrıca AH’de insülin reseptör yolağında yer alan fosfo-AKT (protein kinaz B) ve fosfo-glikojen sentaz kinaz-3β (GSK3β) gibi hücre içi bileşenlerinin azaldığı kanıtlanmıştır. Tip 2 diyabet ve AH’deki patolojik süreçlerin altında yatan ortak moleküler mekanizmalar nedeniyle, AH tedavisinde diyabette endike olan tedavi protokolleri kullanılmaya başlanmıştır.

Anahtar Kelimeler: Diyabet, Alzheimer, IR, IGF-1R, p-AKT, GSK3β, amiloid β, tau

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