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Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats
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Original Article
VOLUME: 4 ISSUE: 3
P: 92-98
December 2016

Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats

Bezmialem Science 2016;4(3):92-98
DOI: 10.14235/bs.2016.788
Meltem KUMAŞ 1
Mukaddes EŞREFOĞLU 2
Nihan BAYINDIR 3
Meryem IRAZ 4
Sıddıka AYHAN 5
Sedat MEYDAN 5
1. Medical Laboratory, Bezmialem Vakıf University Health Care Vocational High School, İstanbul, Turkey
2. Division of Basic Medical Sciences, Department of Histology and Embryology, Bezmialem Vakıf University, İstanbul, Turkey
3. Division of Basic Medical Sciences, Department of Medical Microbiology, Bezmialem Vakıf University, İstanbul, Turkey
4. Division of Basic Medical Sciences, Department of Medical Biochemistry, Bezmialem Vakıf University, İstanbul, Turkey
5. Division of Basic Medical Sciences, Department of Anatomy, Bezmialem Vakıf University, İstanbul, Turkey
No information available.
No information available
Received Date: 23.11.2015
Accepted Date: 22.01.2016
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ABSTRACT

Objective:

We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats.

Methods:

Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels.

Results:

Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05).

Conclusion:

Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.

Keywords: Cadmium, curcumin, oxidative stress, interleukin, procalcitonin, C-reactive protein

References

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