ABSTRACT

The aim of the present study was to examine a possible association between inflammation, as indicated by High-sensitivity C-reactive protein (HsCRP) and neutrophil/ lymphocyte ratio (NLR), and the complexity and severity of coronary artery disease assessed using syntax severity score (SSS) in patients with acute coronary syndrome (ACS).

Patients with symptoms suggestive of ACS who were admitted within 6 h of onset and who underwent coronary angiography were enrolled in the study. According to NLR, we divided patients into two groups: group 1 (NLR≤2.7) and group 2 (NLR>2.7). According to SSS, patients were divided into two groups: group 1 including low scores and group 2 including intermediate and high scores. Statistical analysis was performed using chi-square test and Mann–Whitney U test.

A total of 87 patients (65 males and 22 females) with acute myocardial infarction (AMI; 57 ST-se AMI and 30 non-ST-se AMI) were included in this study. Patients were classified into low (NLR≤2.7, n=63) and high (NLR>2.7, n=24) NLR groups. Univariate a>nalysis demonstrated that SSS was significantly higher in high NLR group than in low NLR group (23.6±12.7 versus 13.9±8.7, p<0.001). Similar to NLR, significant correlation was revealed among HsCRP, troponin levels, and SSS that indicated their predictive value in the severity of AMI.

In present study, we showed NLR to be an independent predictor of hemodynamically significant coronary artery stenosis as measured using SSS.

Keywords: Neutrophil-to-lymphocyte ratio, syntax severity score, acute coronary syndrome