ÖZET
Amaç:
Bu çalışmanın amacı timpanoskleroz (TS) hastalarında serum bone sialoprotein (BSP) seviyelerini araştırmaktır.
Yöntemler:
Yirmi dört TS hastası ve 24 asemptomatik sağlıklı gönüllü çalışmaya dahil edildi. Çalışmamızda iki grup vardı: kronik otitis media ameliyatı geçirmiş ve timpanosklerotik plakları olan hastalardan oluşan TS grubu (24); ve kulak problemi olmayan sağlıklı bireylerden oluşan kontrol grubu (n=24). Serum BSP seviyeleri ölçüldü ve sonuçlar iki grup arasında karşılaştırıldı.
Bulgular:
Timpanoskleroz grubunda 15 kadın ve 9 erkek hasta vardı. Kadınların yaşları 24 ile 54 arasında değişirken, erkeklerin yaşları 34 ile 55 arasında değişmekteydi ve yaş ortalaması sırasıyla 40,46±9,75 ve 43,11±6,77 idi. Kontrol grubunda 14 kadın ve 10 erkek vardı. Kadınların yaşları 30 ile 48 arasında değişirken, erkeklerin yaşları 27 ile 47 arasında değişmekteydi ve yaş ortalaması sırasıyla 40,25±5,28 ve 38,4±27,08 olarak saptandı. BSP düzeyleri karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulundu (p=0,001). Ek olarak, BSP ile işitme seviyeleri arasında pozitif orta düzeyde bir korelasyon vardı.
Sonuç:
Serum BSP düzeyleri TS grubunda kontrol grubundan daha yüksekti ve TS üzerinde bir etkisi olabilir. Çok sayıda hasta üzerinde serum ve doku BSP seviyelerini araştıran yeni çalışmalar, BSP’nin TS üzerindeki etkilerini doğrulamak için tasarlanmalıdır.
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