ÖZET

Amaç:

Bu çalışmada endometrioid tip evre 1 endometriyal kanser (EK) olgularında lenfovasküler alan invazyonun (LVAİ) prognostik öneminin araştırılması, genel sağkalım ve hastalıksız sağkalım üzerine etkisinin belirlenmesi amaçlanmıştır.

Yöntemler:

Ankara Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim Araştırma Hastanesi Jinekolojik Onkoloji Kliniği’nde opere edilmiş 611 evre 1 endometrioid tip EK olgusunun verileri retrospektif olarak tarandı. Olguların demografik özellikleri, klinik bulguları, patoloji verileri, takip ve nüks bilgileri hasta dosyaları ve hastane sistemi üzerinden toplandı. Elde edilen veriler doğrultusunda LVAİ’nin sağkalım üzerine olan etkisi araştırıldı.

Bulgular:

Altı yüz on bir evre 1 endometrioid tip EK olgusunun 52’sinde LVAİ olduğu saptandı. Olguların 489’u (%80) evre 1A iken 122’si (%20) evre 1B idi. Takip süresinde 26 (%4,3) hastada nüks gerçekleşti. Nüks olan 26 hastanın 4’ünde (%15,3) LVAİ tespit edilmişti. Çalışma süresinde LVAİ pozitif hastalarda 5 yıllık hastalıksız sağkalım %88,7 iken, 5 yıllık genel sağkalım oranı %91,6 idi. Yaş >60 yıl (tehlike oranı [TO] 4,08, %95 güven aralığı [GA] 1,57-10,59; p=0,004) ve tumor boyutu >2,8 cm ([TO] 2,48, %95 GA 1.001-6.148; p=0,05) olması genel sağkalıma etki eden bağımsız risk faktörleri olarak bulundu.

Sonuç:

Bu çalışmada, evre 1 endometrioid tip EK olgularında LVAİ’nin genel sağkalım ve hastalıksız sağkalım üzerinde anlamlı bir etkisi bulunmamıştır. Bu bilginin geniş kapsamlı çalışmalarla desteklenmesi gerekmektedir.

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Evre 1 Endometrioid Tip Endometriyal Kanser Olgularında Lenfovasküler Alan İnvazyonunun Prognostik Önemi

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References