Inherited Epilepsies


  • Halil Aziz VELİOĞLU
  • Muhammed Yunus BEKTAY

Received Date: 14.02.2019 Accepted Date: 16.07.2019 Bezmialem Science 2020;8(2):182-188

Mutations in genes encoding the formation of ion channels may cause epileptic syndromes. These epileptic syndromes are generally divided into generalized and partial epilepsies. Among the causative agents of generalized epilepsy showing mendelian or non-mendelian inheritance; mutations in sodium channel, calcium channel, GABAA receptor and nicotinic receptor can be listed. Generalized epilepileptic syndromes with mendelian inheritance are Genetic Epilepsy With Febrile Seizures Plus, Autosomal Dominant Juvenile Myoclonic Epilepsy, and Epilepsy Associated With CLCN2 Gene Mutation. Generalized epileptic syndromes with non-mendelian inheritance are JME and Juvenile Absence Epilepsy With Generalized Tonic-Clonic Seizures. The epilepsies of newborns and infants with a single gene inheritanceare classified into three categories: Benign Familial Neonatal Convulsions, Benign Familial Infantile Convulsions, and Benign Familial Neonatal-Infantile Seizures. Autosomal dominant partial epilepsies are examined under the headings of Autosomal Dominant Nocturnal Frontal Lobe Epilepsy, Familial Mesial Temporal Lobe Epilepsy, Familial Lateral Temporal Lobe Epilepsy, and Autosomal Dominant Partial Epilepsy With Auditory Features. While various mutations in different ion channels can produce similar phenotypes, a certain mutation on the same gene can cause different phenotypes. This review provides a summary of the epilepsy classification on the genetic basis and pathophysiological effects of neural channelopathies causing epileptic syndromes.

Keywords: Epilepsy, channelopathies, inherited epilepsy, genetic mutations

Inherited Epilepsy Syndromes


Epilepsy describes a heterogeneous group of paroxysmal diseases thought to occur as a result of disturbances in neural networks. Around 50 million people around the world live with epilepsy. The estimated rate of patients with active epilepsy who still have seizures or need treatment is between 4 and 10 per 1000 people in the general population. This rate is between 7 and 14 per 1000 people in low-and middle-income countries. Globally, an estimated 2.4 million people are diagnosed as having epilepsy each year. In high-income countries, the incidence is between 30 and 50 per 100,000. In low-and middle-income countries, this figure has been recorded as double or higher. About 80% of people with epilepsy live in low-and middle-income countries. Epilepsy accounts for 0.6% of the global disease burden and leads to significant economic burden due to health care needs, early death and lost work productivity (1).

Studies show that the most common forms of idiopathic epilepsy in particular have inherited characteristics (2-6). Genes inherited by individuals from their families cause conformational mutations in ion channels. As a result of these mutations, unwanted neuronal firing occurs as a result of electrical potential changes in the cell and thus seizures are observed (1).

Ion channels play an important role in the creation and control of neuronal stimulation. With the discovery of mutations in genes that encode the formation of the ion channel, it has been shown that the issue is less or more stimulation of the affected tissues in various inherited neurological diseases. Ion channel disorders in other words, channelopathies are epilepsies in the idiopathic form, accounting for one-third of all epilepsies (7). Neuronal ion channels including voltage-gated channels (Na+, K+, Ca2+, Cl-) and ligand-gated channels (nicotinic ACh receptors, GABA receptors) have a role in the formation of hereditary epilepsies.

The genotype-phenotype relationship in epilepsy is quite complex. Different mutations in the same gene can cause phenotypes of various types (allelic heterogeneity), while mutations occurring in multiple different ion channels can cause similar phenotypes (locus heterogeneity). In addition, due to factors such as age and maturation of the brain, even the same mutation in the same gene can cause different phenotypes (2-6). These genetic changes and the epilepsies caused by them are given in Table 1.

Neuronal channelopathies were originally described based on genetic chain studies. Increased number of epileptic syndromes are usually included in neuronal channelopathies, and these canalopathies often begin at a certain age. The channelopathies include generalized epilepsies such as Genetic Epilepsy With Febrile Seizures Plus (GEFS+) associated with sodium channel and GABRG2 (GABAA) receptor mutations (8). Also focal epilepsies such as BFNC associated with potassium channel mutations and autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) associated with neuronal nicotinic receptor mutations are found in these channelopathies. Juvenile Myoclonic Epilepsy (JME)  and Absans Epilepsy, which are forms of idiopathic generalized epilepsy, may be due to mutations in Ca2+ channels. Furthermore, mutations in Cl- channel gene were found to be associated with certain types of epilepsies (9).

The aim of this study is to explain the types of hereditary epilepsies and the causes of these epilepsies. For this purpose, Mendelian and non-Mendelian idiopathic generalized epilepsy syndromes will be explained in the first part of the article. Then, partial epilepsies observed in newborn and children with single gene inheritance and partial epilepsies with automosomal dominant transition will be discussed. Later, types of epilepsy associated with paroxysmal dyskinesias, episodic ataxia and myokymia will be evaluated under the main heading of “channelopathies associated with epilepsies and other paroxymal neurological disorders”. Finally, we will focus on epilepsy genes that are not associated with the ion channel.

Generalized Epilepsy Sydromes

Mendelian Idiopathic Generalized Epilepsy Syndromes

Genetic Epilepsy With Febrile Seizures Plus (GEFS+)

GEFS+ was first described in 1997 by two scientists, Ingrid Scheffer and Samuel Berkovic (10). Febrile seizures (seizures occuring when body temperature is >38 oC) are the most common neurological disorder affecting 3% of children under 6 years of age Gardiner, M. In GEFS+, fever seizures often begin at age before 6 months and continue after 6 years of age with or without fever (11). The SCN1A, SCN2A, SCN1B and GABRG2 ion channel genes are thought to have a role in GEFS+ epilepsy (12). Mutations in these genes result in epilepsy syndromes belonging to the GEFS+ family showing autosomal dominant inheritance (13). As a result of mutations in these genes, epilepsy syndromes belonging to the GEFS + family that show autososomal dominant transition given in Table 2 (14). The most common phenotype is FS+; where febrile seizures (FS) continue after 6 years of age as tonic-clonic seizures without fever. Less common phenotype is myoclonic-astatic epilepsy syndrome with febrile seizures which is characterized by absance, myoclonic or atonic seizures (10,14,15).

The genetic heterogeneity of GEFS+ has been expressed in detail through loci. First locus (19q) was defined on the long arm of 19th chromosome (GEFS1) and corresponded to the gene encoding the sodium channel β1 subunit (SCN1B). Second locus (2q) was defined on the long arm of 2nd chromosome (GEFS2) and corresponded to the gene encoding the sodium channel alpha subunit (SCN1A). To date, 9 different missense mutations have been reported in SCN1A. The missense mutation in the SCN2A gene, which encodes the sodium channel α2 subunit, is also localized on 2q and has been identified for the first time in a Japanese family (9). Voltage-gated sodium channels are essential in the production and propagation of the action potential in neuronal tissues. Biochemically, these channels consist of one large alpha subunit and 1 or 2 smaller beta subunits. The alpha subunit alone can show all the functional properties of the voltage-gated sodium channel, but requires beta subunits for normal inactivation kinetics. The mutations identified in sodium channel α and β subunits cause subtle changes in channel gating (increases in persistent sodium current, shifts in the voltage-dependence of steady state inactivation and/or resistance to frequency-dependent cumulative inactivation) which are thought to increase neuronal excitability and thus to predispose affected individuals to seizures (9,16).

Molecular studies have shown that gene mutations in the GABAA receptor subunit occur in GEFS+ syndromes and in the classic idiopathic generalized epilepsy family. In particular GABRG2 gene mutations have been reported to be seen in GEFS+ and childhood absance epilepsy phenotypes. Mutations in the sodium channel subunit have been found mostly in GEFS+, but these mutations can also be seen in classical idiopathic generalized epilepsies (IJE) (13).

Autosomal Dominant Juvenile Myoclonic Epilepsy

JME is a type of seizure that occurs around puberty, characterized by bilateral, single or repetitive, arrhythmic, irregular myoclonic jerks (MJ), observed mostly in the upper extremities. JME accounts for 5-10% of all epilepsies and 20-27% of IJE. The starting age of the JME often varies between the ages of 8-26 years, particularly 12-18 years (11,17). JME is often accompanied by generalized tonic-clonic seizures (JTKN) and less often by also absence seizures. Seizures can usually occur shortly after waking up or with sleep deprivation.

JME is a heterogeneous disease associated with several mutations. Major genetic loci thought to cause JME have been identified as epilepsy juvenile myoclonic 1 (EJM1), epilepsy juvenile myoclonic 2 (EJM2), and epilepsy juvenile myoclonic 3 (EJM3). A mutation in the GABRA1 gene on chromosome 5q34-q35 was identified in 14 members of a French-Canadian family with JME. In that family, the mode of inheritance of JME was autosomal dominant. The cause of seizures is the degradation of ligand-gated ion channels and the reduction of GABA. JME may also occur due to dysfunction in the β4 subunit of voltage-gated calcium channels as a result of mutation in the CACNB4 gene on the 2q22-q23 locus (18). In addition, Cl- channels have been affected as a result of a mutation in the CLCN2 gene on locus 3q26 and JME has developed. It has therefore been determined that various channelopathies can lead to JME. In JME, maternal transition associated with EJM1 has also been shown. JME is transmitted five times more to children from mother than from father (19).

Epilepsy Associated With CLCN2 Gene Mutation

CLC-2, a chlorine channel found in the brain, is particularly found in neurons inhibited by GABA and has the role in providing the low intracellular Cl- concentration required for the response of the inhibitory GABA (20,21). Disturbance of neuronal inhibitory system controlled by the inward current of Cl-can result in epilepsy. The CLCN2 gene mutation encoding CLC-2 (voltage-gated Cl- channel) has been found to be associated with IJE in three families. Two families were found to have inherited autosomal dominant patterns, and the third family had epilepsy in only one generation. The phenotype is very diverse, including patients with JME, absence epilepsies (childhood absence epilepsy  and juvenile absence epilepsy) and isolated generalized tonic-clonic seizures (GTCS) (20,21).

Epilepsy Associated With Mutations in Calcium Channel Subunits

Mutations in CACNB4, the calcium channel ß4 subunit gene, have been identified in two small families with two affected individuals in each. In one of these families, the phenotypes overlapped with JME. In a small family with childhood absence epilepsy, another calcium channel subunit gene, CACNA1, was found to be mutated. Functional analysis of the mutation (R2162H) has shown that P/Q type CA++ channels have function gain by influencing G-protein modulation (22).

Non-Mendelian Idiopathic Generalized Epilepsies

It shows a complex inheritance of IJEs. In IJE, the original characteristic features of symptoms often overlap, and different IJE syndromes are collected in a single lineage. A locus identified on chromosome 18 is responsible for various IJE syndromes with adolescent onset including JME and juvenile epilepsy with absence and generalized tonic-clonic seizures (10). Analyses with polymorphism based on a single nucleotide have shown that the malic enzyme 2 haplotype increases the risk of IJE in homozygous cases. This enzyme is found in the neuronal synthesis of GABA. Blocking GABA synthesis facilitates the emergence of adolescent-onset IJE (12).

Fokal (Parsiyel) Epilepsies

Idiopathic Focal Epilepsies of Newborns and Infants Associated With Single Gene Inheritance

Benign Familial Neonatal Convulsions (BFNC)

Benign familial neonatal convulsions (BFNC) is a rare epileptic syndrome with dominant heredity characterized by frequent and short seizures that typically begin in the early days of life and disappear spontaneously after weeks or months. In very rare cases, adulthood epilepsy occurs (~10% of people). Although it has been recognized as generalized epilepsy in the ILAE classification in 1989, seizures have several clinical manifestations including tonic attacks, apnea, clonic, focal, and autonomic features (23). The majority of patients with BFNC have KCNQ2 gene mutations on chromosome 20q13.3 and some of them have KCNQ3 gene mutations on chromosome 8q24. In the nervous system, the products of the KCNQ2 and KCNQ3 gene combine to form potassium channels that produce M-current (24). M-current regulates neuronal excitability by reducing the tendency for repetitive firing. Neuronal M-currents are activators of other neurotransmitter receptor types but are inhibited by muscarinic acetylcholine agonists. Mutations in KCNQ2 or KCNQ3 decrease function in K+ channels encoded by negative mechanism, consistent with autosomal dominant inheritance patterns of BFNC (16,25). Detailed examination of the KCNQ2/KCNQ3 complex, which contained one of the KCNQ2 mutations, showed that neonatal epilepsy was the result of mutation leading to changes in the K+ channel gate and the M-current (26).

Benign Familial Infantil Convulsions (BFIC)

BFIC is an autosomal dominant disease seen in infancy. It is characterized by motor arrest along with short seizures and slow deviation of the head and eyes to one side. During the seizure, bruising, hypertonia and unilateral lip wobble are observed. Seizures begin at age of 3-12 months. Three locuses are responsible for the occurrence of this epilepsy. A mutation has been observed in 4 Italian families on chromosome 19q, in 7 French and Argentine families on chromosome 16p12-q12 (short arm of 16th chromosome) and on chromosome 2q24 in another 8 Italian families. No phenotypic differences have been observed between families with symptoms associated with mutations in these different chromosomes (27).

Benign Familial Neonatal-Infantil Convulsions (BFNIC)

Benign familial neonatal-infantil convulsions (BFNIC) syndrome is one of the autosomal dominant benign familial epilepsy syndromes seen in the first year of life. BFNIC syndrome begins in the range of 2 days to 7 months and shows symptoms that remain phenotypically between BFNC and BFIC. The mutation in the subunit gene SCN2A, which encodes the Na+ channel, is the main cause of this disease and BFNIC have been found in 8 families until today (28).

Autosomal Dominant Partial Epilepsies

Genetic etiology is widely accepted in generalized epilepsies, but focal or partial epilepsies are mostly based on environmental factors such as birth accidents, trauma, infections, and brain lesions such as tumors and vascular damage. Despite this, there has been an increase in the diagnosis of families with dominant hereditary partial epilepsies over the past decade. Major familial focal epilepsies are ADNFLE, familial mesial temporal lobe epilepsy (FMTLE), familial lateral temporal lobe epilepsy (FLTLE), and familial partial epilepsy with variable foci (FPEVF) (29,30). So far, responsible genes have been identified only in ADNFLE (genes encoding ion channel subunits) and FLTLE (genes encoding non-ion channel subunits) (9,31).

ADNFLE is seen in almost every period from early childhood to adulthood, but most often starts around the age of 10 years. Almost all seizures occur in sleep. Mesial temporal lobe epilepsy was first described in 1994. A year later it was determined that the gene responsible for causing this epilepsy was on region 20q13.2. The gene CHRNA4 that encoded the neuronal nicotinic acetylcholine receptor (nACh-R) was then sequenced (this was also the first gene found in 1995). Another localization that causes this type of epilepsy has been found on the 15q region where different neuronal nicotinic acetylcholine receptor subunits exist. Mutations of α4 and β2 subunits of nicotinic acetyl choline receptor (CHRNA+ and CHRNB2) are the proven causes of ADNFLE (32).

Channelopathies Associated With Epilepsies or Other Paroxysmal Neurological Diseases

Epilepsies Associated With Paroxysmal Dyskinesias

Infantile convulsions and choreoathetosis (ICCA) syndrome is a syndrome associated with familial infantile convulsions that occur in association with paroxysmal choreoathetosis. Afebrile partial seizures occur between 3-12 months. Seizures begin with psychomotor arrests and deviation of the head and eyes, and sometimes become secondary generalised. Paroxysmal choreoathetosis begins in most patients between the ages of 5 and 9 years and tends to decrease in adulthood. A mutation on the 16p12-q12 locus has been observed to cause ICCA syndrome (33).

Generalized epilepsy and paroxysmal dyskinesia is a syndrome that accompanies generalized epilepsy, and paroxysmal dyskinesia is linked to chromosome 10q22. The mutation has been identified in the alpha subunit of the calcium-sensitive potassium channel. The mutant calcium-sensitive potassium channel has a noticeably larger macroscopic current. Single channel records show an increase in open-channel probability due to a 3-5-fold increase in Ca++ sensitivity. It has been suggested that increasing calcium-sensitive potassium channels in vivo would induce rapid repolarization of the action potential, leading to increased excitability, and would result in generalized epilepsy and paroxysmal dyskinesia, allowing these neurons to fire at a faster rate (34).

Epilepsies Associated With Episodic Ataxia

Another ion channel disorder with impaired excitability in the central nervous system is Episodic ataxia type 1 (EA-1) with myokymia. The disorder is mostly in the cerebellum. Patients complain of short kinesiogenic walking attacks, limb ataxia, or cerebellar dysarthria. In addition, partial epileptic seizures have also been reported in four families. Genetic analyses with EA-1 have indicated a link to chromosome 12p13. Mutations have also been found in the KCNA gene encoding the K+ channel Kv1.1 (35).

Episodic ataxia type 2 (EA-2) with IJE: Mutations in the CACNB4 gene encoding the voltage-gated calcium channel on chromosome 2q22-23 cause IJEs and hereditary episodic ataxia (36). This gene encodes the β4 subunit of the protein that regulates the function of P/Q-type neuronal calcium channels. Voltage-gated calcium channels, especially P/Q-type channels, are important for neurotransmitter release in the central nervous system. The same gene has been also reported to be mutant in patients with sole IJE.

Absans epilepsy with episodic ataxia: A heterozygous mutation in the CACNA1A gene encoding the subunit of the P/Q type voltage-gated Ca+2 channel is the cause in individuals with complex phenotypes where absence epilepsy is associated with episodic ataxia (37).

Myokymia-Associated Epilepsies

BFNC that occur after myokymia have been described in two families. Muscular over-excitability resulted from the variable excitability of the lower motor neuron. Unlike other neurological diseases identified associated with epilepsy mentioned above, myokymia activity is continuous (38). Mutations in KCNNQ2 can cause typical BFNC and peripheral nerve stimulation that are not related to epilepsy, but also cause epilepsies of neonatal and early infancy with myokymia (39).

Non-Ion Channel Epilepsy Genes

Autosomal dominant partial epilepsy with auditory features (ADPEAF) is characterized by simple partial seizures with hallucinations or illusions, dream state, visual illusions, or speech disorders suggesting a lateral temporal source. If it spreads to the mesial temporal or extratemporal structures, it may develop into complex partial seizures (40). Magnetic resonance imaging results of patients are mostly normal. The onset time of the disease varies between youth and early adulthood. A genetic examination has shown a mutation in the LGI1 gene (leucine-rich glioma inactivated-1) on chromosome 10q24. This gene is involved in protein-protein interaction with ligand binding and in the development of the nervous system. LGI1 is the only gene responsible for temporal lobe epilepsy. This gene is also the only non-ion channel gene (40) that can be identified in idiopathic epilepsy. In some families with IJE (JME or lone GTCS), a second gene, EFHC1, which is not a direct ion channel gene, is mutant. This gene encodes a protein that interacts with R-type voltage-gated calcium channels and modulates these channels and has apoptotic activity. The third gene is the ATP1A2 Na+, K+-ATPase pump gene (41) on chromosome 1q23. This gene does not encode an ion channel but is involved in ion transport. This gene has been found to be a mutant in a family that includes patients with an idiopathic form of epilepsy and migraine (9).


In general, idiopathic epilepsies can be evaluated as ion channel pathologies (38,42). All mutations cause functional change. It is thought that channelopathies can reduce the transmembrane chloride gradient required for GABAergic inhibition, leading to membrane depolarization and hyperexcitability. There are many other diseases, episodic or non-episodic, caused by channel pathologies other than epilepsy. But channel pathologies are not the only cause of epilepsy. Non-ion channel genes, LGI1 and ARX, have emerged as major causes of specific epilepsy syndromes during the past years (26). As new genes are discovered and the functional consequences of disease-causing mutations are revealed, the genetic field of epilepsies will continue to evolve.

With genetic information from spontaneous mutant or genetically mutantized epilepsy animal models, or from epileptic humans, it has been understood that certain epilepsy syndromes are ion channel diseases. Idiopathic epilepsies are usually caused by mutations in genes that encode ion channels (9). Therefore, dysfunction in ion channels is associated with epilepsy. The complete elucidation of the functioning and genetic structure in ion channels will lead to the emergence of new approaches in the treatment of epilepsies mentioned above.


Peer-review: Externally peer reviewed.

Authorship Contributions

Concept: H.A.V., Design: H.A.V., Data Collection or Processing: M.Y.B., Analysis or Interpretation: M.Y.B., Literature Search: H.A.V., Writing: H.A.V., M.Y.B.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.


  1. World Health Organization. Epilepsy [Internet]. [cited 2019 Jan 28]. Available from:
  2. Inouye E. Observations on forty twin index cases with chronic epilepsy and their co-twins. J Nerv Ment Dis. 1960;130:401-16.
  3. Corey LA, Berg K, Pellock JM, Solaas MH, Nance WE, DeLorenzo RJ. The occurrence of epilepsy and febrile seizures in Virginian and Norwegian twins. Neurology 1991;41:1433-6.
  4. Marshall AG, Hutchinson EO, Honisett J. Heredity in common diseases: A retrospective survey of twins in a hospital population. Br Med J. 1962;5270:1-6.
  5. Schiottz-Christensen. GENETIC FACTORS IN FEBRILE CONVULSIONS An Investigation of 64 Same-Sexed Twin Pairs. Acta Neurol Scand. 1972;48:538-46.
  6. Sillanpää M, Koskenvuo M, Romanov K, Kaprio J. Genetic factors in epileptic seizures: evidence from a large twin population. Acta Neurol Scand 1991;84:523-6.
  7. Lerche, H., Jurkat-Rott, K., Lehmann-Horn F. Ion channels and epilepsy. Am J Med Genet - Semin Med Genet. 2001;106:146-59.
  8. Scheffer IE, Zhang YH, Jansen FE, Dibbens L. Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? Brain Dev [Internet]. 2009;31:394-400.
  9. Kurian M, Picard F. Inherited epilepsy syndromes and channelopathies. Epileptologie. 2006;23:75-85.
  10. Scheffer IE, Berkovic SF. The genetics of human epilepsy. Trends in Pharmacological Sciences. 2003.
  11. Dervent A, Gökyiğit A. Çocukluk ve ergenlikte başlayan idiyopatik jeneralize epilepsiler. Epilepsi 2014;20:13-22.
  12. Gardiner M. Genetics of idiopathic generalized epilepsies. Epilepsia [Internet] 2005;46(Suppl 9):15-20.
  13. Zhang, Y-H. ve Scheffer I (2010). Generalized epilepsy with febrile seizures plus and classical idiopathic generalized epilepsy. Neurol Asia 2010;15(Supplement 1):3-4.
  14. Harkin LA, McMahon JM, Iona X, Dibbens L, Pelekanos JT, Zuberi SM, et al. The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain 2007;13:843-52.
  15. Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain 1997;120:479-90.
  16. Wallace RH, Scheffer IE, Barnett S, Richards M, Dibbens L, Desai RR, et al. Neuronal Sodium-Channel 2001;859-65.
  17. Renganathan R, Delanty N. Juvenile myoclonic epilepsy: under-appreciated and under-diagnosed. Postgrad Med J [Internet] 2003;79:78-80.
  18. Robyn Wallace. Identification of a New JME Gene Implicates Reduced Apoptotic Neuronal Death as a Mechanism of Epileptogenesis. Epilepsy Curr 2005;5:11-3.
  19. Turan OD. Juvenil myoklonik epilepsi hastaları ve asemptomatik akrabalarında uyku deprivayonlu kısa dönemli uykuda EEG özellikleri ve kognitif fonksiyonların değerlendirilmesi. 2009.
  20. D’Agostino D, Bertelli M, Gallo S, Cecchin S, Albiero E, Garofalo PG, et al. Mutations and polymorphisms of the CLCN2 gene in idiopathic epilepsy. Neurology 2004;63:1500-2.
  21. Saint-Martin C, Gauvain G, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, et al. Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. Hum Mutat 2009;30:397-405.
  22. Heyes S, Pratt WS, Rees E, Dahimene S, Ferron L, Owen MJ, et al. Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Prog Neurobiol [Internet] 2015;134:36-54.
  23. Zhang YH, Burgess R, Malone JP, Glubb GC, Helbig KL, Vadlamudi L, et al. Genetic epilepsy with febrile seizures plus. Refining the spectrum. Neurology 2017;89:1210-9.
  24. Rogawski MA. Rogawski00 2000;1-6. Available from: papers3://publication/uuid/CAF83C20-944B-4128-B979-5B120146CE99
  25. Schroeder, B.C., Kubisch, C., Stein, V. Ve Jentsch TJ. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Macmillian Publ Ltd Nature 1998;396.
  26. Bebek N. ve Baykan B. Epilepsilerin genetik yönü ve idyopatik epilepsi genetiğinde son gelişmeler. J Neurol Sci [Turkish] 2006;23:70-83.
  27. Callenvach, P.MC., De Coo, R.FM., Vein, A.A., Arts, W.F.M., Oosterwijk, J.C., Hageman, G., Houten, R.T., Terwindt, G.M., Lindhout, D., Frants, R.R. ve Brouwer OF. Benign familial infantile convulsions: a clinical study of seven Duch families. Eur J Paediatr Neurol 2002;6:269-83.
  28. Herlenius, E., Heron, S.E., Grington, B.E., Keay, D., Scheffer, I.E., Mulley, J.C. ve Berkovic SF. SCN2A mutations and benign familial neonatal-infantile seizures: the phenotypic spectrum. Epilepsia 2007;48:1138-42.
  29. Engel J. Mesial Temporal Lobe Epilepsy: What Have We Learned? Neurosci [Internet] 2001;7:340-52.
  30. Cersósimo R, Flesler S, Bartuluchi M, Soprano AM, Pomata H, Caraballo R. Mesial temporal lobe epilepsy with hippocampal sclerosis: Study of 42 children. Seizure 2011;20:131-7.
  31. De Marco E V., Gambardella A, Annesi F, Labate A, Carrideo S, Forabosco P, et al. Further evidence of genetic heterogeneity in families with autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy Res 2007;74:70-3.
  32. Trivisano M, Terracciano A, Milano T, Cappelletti S, Pietrafusa N, Bertini ES, et al. Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy. Epilepsia. 2015;56:e53-7.
  33. Rochette J, Roll P, Fu YH, Lemoing AG, Royer B, Roubertie A, et al. Novel familial cases of ICCA (infantile convulsions with paroxysmal choreoathetosis) syndrome. Epileptic Disord 2010;12:199-204.
  34. Guerrini R, Sanchez-Carpintero R, Deonna T, Santucci M, Bhatia KP, Moreno T, et al. Early-onset absence epilepsy and paroxysmal dyskinesia. Epilepsia 2002;43:1224-9.
  35. Akay, A., Turanlıgil-Sümer, N.C., Uyanıkgil Y. İyon kanalları ve epilepsi patojenezindeki rolleri. Arşiv Kaynak Tarama Derg 2010;19:72.
  36. Escayg, A., De Waard, M., Lee, D.D., Bichet, D., Wolf, P., Mayer, T., Johnston, J., Baloh, R., Sander, T., ve Meisler MH. Coding and noncoding variation of the human calcium-channel ß4-Subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am J Hum Genet 2000;66:1531-9.
  37. Reid CA, Berkovic SF, Petrou S. Mechanisms of human inherited epilepsies. Prog Neurobiol 2009;87:41-57.
  38. Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A [Internet] 2001;98:12272-7.
  39. Weckhuysen S, Mandelstam S, Suls A, Audenaert D, Deconinck T, Claes LRF, et al. KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy. Ann Neurol [Internet] 2012;71:15-25.
  40. Browne, T.R. ve Holmes GR. Epilepsi El Kitabı. İstanbul: İstanbul: Güneş Tıp Kitabevleri; 2013.
  41. Deprez L, Weckhuysen S, Peeters K, Deconinck T, Claeys KG, Claes LRF, et al. Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia 2008;49:500-8.
  42. Fujiwara T, Sugawara T, Mazaki-Miyazaki E, Takahashi Y, Fukushima K, Watanabe M, et al. Mutations of sodium channel α subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures. Brain 2003;126:531-46.