Objective:

Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cell distribution width (RDW), mean platelet volume (MPV), and C-reactive protein (CRP) levels in patients with essential hypertension.

Methods:

Sixty-two patients with essential hypertension were enrolled in the study between January 01, 2013 and December 31, 2013. The presence of cardiovascular disease was assessed by echocardiography, coronary angiography, and stress test. The patients were divided into two groups according to the absence (group 1) or presence (group 2) of cardiovascular complications. Data were collected for serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW and were compared between the two groups.

Results:

Cardiovascular complications were determined in 23 patients (37.1%). In groups 1 and 2, the CRP level was 4.89 and 3.64, RDW was 13.8 and 13.5, serum uric acid level was 5.57±1.23 and 5.33±0.8, spot urine uric acid level was 65.13±29.11 and 61.94±18.13, and MPV was 7.7 and 7.2, respectively. A significant difference was not found between the two groups in terms of serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW (p>0.05). In group 2, there was a significant negative correlation between the glomerular filtration rate and RDW and between RDW and MPV and positive correlation between CRP levels and RDW (p<0.01, p <0.05, and p<0.05, respectively).

Conclusions:

Serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW cannot predict the development of cardiovascular disease in patients with essential hypertension.

Keywords: Hypertension, uric acid, CRP, MPW, RDW