Original Article

Evaluation of Factor XII Activity in Women with Recurrent Miscarriages


  • Nilay KARACA
  • Lebriz Hale AKTÜN

Received Date: 05.07.2017 Accepted Date: 23.10.2017 Bezmialem Science 2018;6(4):279-282


Our aim is to evaluate factor XII activity in women with recurrent miscarriages by active partial thromboplastin time (aPTT) measurement.


This study was conducted in 145 patients admitted to our clinic with recurrent miscarriages between 2014 and 2016. The inclusion criteria were two consecutive or three non-consecutive miscarriages in low-grade patients under the 12th gestational week. Factor XII activity was assessed by aPTT.


The mean age of women with 145 recurrent miscarriages included in the study was 28.4 (±7.6) years and the mean number of abortions was 2. The mean factor XII activity was 106.19±33.62% (range, 90-200). Factor XII activity was found to be <60% in 6.8% (n=10) of the patients. There were a total of three cases with <35% factor XII activity. Factor XII activity was found to be >60% in 93.2% (n=135) of the patients.


In the case of recurrent miscarriages, at least aPTT measurement during routine thrombophilic factors may be useful for diagnosis. Investigation of factor XII may be suggested to the patient have prolonged aPTT.

Keywords: Recurrent miscarriages, aPTT, Factor XII